This research was carried out in Thoai Son district (on rice crop), Cho Moi (on fruit crop) and Chau Thanh district (on vegetable crop) of An Giang province to evaluate the effects of Chlorpyrifos and Paraquat in agricultural production on farmers’ health and environment in An Giang province. Most farmers chose herbicides with fluid leading features, killing the green part of the leaf or a combination of both, or they just chose from their habits (90%). Only 6% of farmers knew the name of the active subtances of the herbicides in general and 11% of farmers knew the origin of Paraquat, in which the farmers in An Giang took the highest percentage. For the pesticide, the first choice of farmers was the chemicals with fluid leading and fast killing features, then chemicals with quick exposure, poisonous taste and fast killing, then the last one was the less poisonous pesticides. There were 90.9% of farmers using Chlorpyrifos for pest management without knowing the name of this active substance. Most farmers thought that the active sustances Paraquat and Chlorpyrifos affected badly to human health and environment (92.2%) – particularly the percentage of agreement on the element that polluted the water to the alarm level (76.1%). However, the extent of use was still very high because they have not had any solution to replace these two active sustances in agricultural production.